克罗米酮对男性低促性腺素性功能减退症有效

芝加哥（路透社健康版）1同月四日报道：据刊出在12同月出版的《生育与后代》周报的一项调查报告援引克罗米苯对部分偏高促新功能性腺素新功能性新功能大不如前的男新功能性高血压不利于。来自布里斯托尔阿拉巴马大学的该调查报告的第一所作Scott J. Whitten助手在遵从路透通讯社采访时问道：“原发新功能性或获得新功能性HH高血压在遵从侵害新功能性更大和更为昂贵的治疗（例如注射促新功能性腺激素类）同一时间透过4个同月的克罗米苯试验新功能性治疗是不利于的。”Whitten助手和同事研究了克罗米苯对10名HH男新功能性高血压（HH是导致男新功能性后代的少见因素）是否有效。调查报告称克罗米苯治疗1年后，4名芝诺(氏)综合征高血压中都只有一名高血压的胚胎含量增加而全垂体新功能大不如前症高血压的胚胎缺失患者均没有取得更佳。只不过，该调查报告援引3名成年人患病的原发新功能性HH男新功能性高血压经过3个同月克罗米苯的治疗胚胎含量有了明显增加。目同一时间为止该组高血压已经有两名趋于稳定了生育能力。Whitten助手问道：“除非对克罗米苯治疗没有反应，我们不会因为副作用停止对高血压应用于该口服。”最后所作说明了问道：“因为状况有限，对HH高血压促新功能性腺激素类口服和克罗米苯的随机研究难以透过，然而利用多系列的严格选项标准对高血压透过标准可能鼓励全面性验证克罗米苯趋于稳定男新功能性偏高生育能力的有效新功能性。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

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主编： 张靖